The first historical reference to Krzeszowice comes from 1286 where the bishop Paweł of Przemanków granted Fryczek Freton of Bytom with a charter for establishing a village organisational unit called "sołectwo" in an already existing village of "Cressouicy", following Magdeburg law.
A church existed here probably in 1337. According to Długosz in the late 15th century there was a wooden St. Martin church in Krzeszowice, as well as a school, a tavern and a parish farm.

In 1555 Krzeszowice became the property of Stanisław Tęczyński and was incorporated into "the county of Tęczyn". Further on it belonged to the families of Opaliński, Czartoryski, Lubomirski, and - after 1816 - the Potocki family.

Following the spa reorganisation caused by discovery of therapeutic springs, in 1778 Duke August Czartoryski built the first baths - the first patients arrived as early as in the next year. Due to the spa's development in 1783-86 the palace of "Vauxhall" was erected, and later in 1819 the building referred to as "the Green Baths"(after 1858 named "Zofia").
The external proof of Krzeszowice's significance was that in 1809-1815 and 1855-1867 the town was the site of a separate region of Krzeszowice, and later the regional court was still residing there, having 29 villages under its jurisdiction.
In 1829 Zofia Potocka founded a hospital for employees of Tęczyn estate, which, following Artur Potocki's order during the October Uprising (1830-31) was rendered available to insurgents seeking refuge in the Republic of Kraków. In 1842-43 "Artur's Refuge House" was built for the poor. One of the most interesting buildings is a Neogothic church erected in 1832 and 1840-44 designed by K.F. Schinkel; the finishing works lasted till 1874.
In 1847 the railway line was built through Krzeszowice, from Kraków to Mysłowice, and in 1850 Krzeszowice was granted the charter for organising fairs.
Due to the nation's thraldom, the local people were involved both in the Kraków Uprising (1846) and in the January Uprising (1863); the neighbouring villages are important points for armament and insurers being smuggled to the Kingdom.

In 1850-55 the Potocki family erected, according to the design of F.M. Lancia, an Italian Renaissance palace. In parallel to the palace construction, a landscape park with English park features was prepared. The palace was inhabited as late as in 1862 and minor reconstructions, in particular of the interior, were made till 1870.
At the end of 19th century Krzeszowice faced the period of intense industrial and urban development. New manufacturing plants were established: [stycharskie(?)] and potter's (c.a. 1880), a steam-powered sawmill (c.a. 1894), a barrel factory (c.a.1894), a factory of facade mortar (1900), a roofing-tile and drain pipe factory and a mineral colour factory (1906), a factory of cement and concrete products (1907).
In 1919 the Community Council applied for granting Krzeszowice with municipal rights, however, as late as on December 3, 1924 the place received the status of a little town. Krzeszowice's municipal rights confirmation took place on October 18, 1933.

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